Two HPV Vaccines Yielding Similar Success

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Are the Two Human Papillomavirus Vaccines Really Similar? A Systematic Review of Available Evidence: Efficacy of the Two Vaccines against HPV

BACKGROUND When the bivalent and the quadrivalent HPV vaccines were marketed they were presented as having comparable efficacy against cervical cancer. Differences between the vaccines are HPV types included and formulation of the adjuvant. METHOD A systematic review was conducted to assess the efficacy of the two vaccines against cervical cancer. Outcomes considered were CIN2+, CIN3+, and AI...

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The HPV L1 VLP vaccines are immensely important developments in public health and the benefits that they promise are immense, offering the opportunity to prevent, in the long term, 80% of cervical cancers, 60% of vulval cancers and 80% of anal cancers in women. In the short to medium term they will prevent at least 90% of genital warts and have a major impact on the incidence of high grade CIN,...

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Cervical cancer and its precursor intra-epithelial lesions are linked to infection by a subset of human papillomavirus (HPV) types, the so-called “high-risk” HPVs, the most prevalent being HPV16 and HPV18. Two prophylactic vaccines containing combinations of the major capsid protein (L1) of HPV16 and HPV18 have been shown to efficiently prevent infection by inducing capsid-specific neutralizing...

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ژورنال

عنوان ژورنال: JNCI: Journal of the National Cancer Institute

سال: 2005

ISSN: 1460-2105,0027-8874

DOI: 10.1093/jnci/dji227